Article

Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

2024-02-26

Abstract excerpt

<title>Abstract</title> <p>The continued evolution of SARS-CoV-2 underscores the need to understand qualitative aspects of the humoral immune response elicited by spike immunization. Here, we combined monoclonal antibody (mAb) isolation with deep B cell receptor (BCR) repertoire sequencing of rhesus macaques immunized with prefusion-stabilized spike glycoprotein. Longitudinal tracing of spike-sorted B cell lineag...

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Literature Corpus work: 1664af8f-38d9-54bd-9017-82a2daddf792
DOI: 10.21203/rs.3.rs-3958951/v1

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