Article

Drug Target Validation in Polyamine Metabolism and Drug Discovery Advancements to Combat Actinobacterial Infectious Diseases

2025-04-11

Abstract excerpt

Actinobacterial natural ecological niches are characterized by variations in the availability of nutrients, resulting in a complex metabolism. Their remarkable ability to adapt to fluctuating nutrient conditions is possible through the utilization of large amounts of substrates. Recent discoveries in bacterial metabolism suggested the importance of polyamine metabolism in bacteria, particularly in those of the ord...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 440d8720-4146-5ca7-abf8-8350c495b567
DOI: 10.20944/preprints202504.0937.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug Target Validation in Polyamine Metabolism and Drug Discovery Advancements to Combat Actinobacterial Infectious DiseasesDOI 10.20944/preprints202504.0937.v1Read

Antibiotics from rare actinomycetes, beyond the genus StreptomycesSemantic proximity Read

Biosynthesis of Antibacterial Iron-Chelating Tropolones in Aspergillus nidulans as Response to Glycopeptide-Producing StreptomycetesSemantic proximity Read

A review on Actinomycetes distribution, isolation, and their medical applicationsSemantic proximity Read

Understanding and manipulating antibiotic production in actinomycetesSemantic proximity Read

Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm?Semantic proximity Read

Purine Acquisition and Synthesis by Human Fungal PathogensSemantic proximity Read

Sulfur Metabolism as a Promising Source of New Antifungal TargetsSemantic proximity Read

New and Old Hot Drug Targets in TuberculosisSemantic proximity Read

Recent advances in understanding StreptomycesSemantic proximity Read

Integrated Bioinformatics-Based Subtractive Genomics Approach to Decipher the Therapeutic Drug Target and Its Possible Intervention against BrucellosisSemantic proximity Read

Pattern-based genome mining guides discovery of the antibiotic indanopyrrole A from a marine streptomyceteSemantic proximity Read

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic eraSemantic proximity Read