Mapping the Trimethoprim-Induced Secondary Metabolome of <i>Burkholderia thailandensis</i>

Abstract excerpt

While bacterial genomes typically contain numerous secondary metabolite biosynthetic gene clusters, only a small fraction of these are expressed at any given time. The remaining majority is inactive or silent, and methods that awaken them would greatly expand our repertoire of bioactive molecules. We recently devised a new approach for identifying inducers of silent gene clusters and proposed that the clinical...

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