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Article

Stringent selection drives convergence toward omicron-like SARS-CoV-2 receptor-binding motifs.

Nature communications - 25 Apr 2026

Shoshany Aviv, Tian Ruojin, Padilla-Blanco Miguel, Hruška Adam, Konar Aditi, Baxová Katarína, Zoler Eyal, Mokrejš Martin, Schreiber Gideon, Zahradník Jiří

Abstract excerpt

In vitro protein evolution can provide powerful insights into the amino acid sequences that underlie key biological functions. Here, we use this to explore the evolutionary trajectories of the SARS-CoV-2 spike protein receptor-binding motif (RBM) binding the human angiotensin-converting enzyme 2 (ACE2), an essential first step in viral infection. Applying stringent selection pressures starting from the Wuhan or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42034607
DOI: 10.1038/s41467-026-72312-z
PMCID: PMC13324855

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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