Article

Artificial Intelligence-Driven Identification of Age- and Treatment-Specific TP53 and PI3K Alterations in Pancreatic Ductal Adenocarcinoma

2026-04-09

Abstract excerpt

<h4>Background</h4> Despite extensive characterization of key oncogenic drivers, pancreatic ductal adenocarcinoma (PDAC) continues to exhibit profound molecular heterogeneity and inconsistent responses to standard therapies, including gemcitabine. The role of pathway-level alterations, particularly in the context of age at onset and therapeutic exposure, remains insufficiently defined. <h4>Methods</h4> In this s...

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Literature Corpus work: 15ff2cdd-37c0-5194-a833-ea6ff05f7f31
DOI: 10.64898/2026.04.07.26350355

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