Article

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

2023-03-27

Abstract excerpt

<h4>Summary</h4> SARS-CoV-2, the cause of the COVID19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. Transcriptomic analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549 cells expressing individual accessory proteins ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). IL11 signaling-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15d113cf-a2f5-5df8-b0e9-080adf4eb8ec
DOI: 10.1101/2023.03.27.534381

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signalingDOI 10.1101/2023.03.27.534381Read

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signalingSemantic proximity Read

Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7bSemantic proximity Read

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progressionSemantic proximity Read

The transcriptomic profiling of COVID-19 compared to SARS, MERS, Ebola, and H1N1Semantic proximity Read

An Integrative Analysis Identifying Transcriptional Features and key Genes Involved in COVID-19Semantic proximity Read

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesisSemantic proximity Read

Omicron-Enhanced Immunosuppressive Effects of SARS-CoV-2 ORF3a and ORF9b Accessory Proteins on Monocytic Inflammatory ResponseSemantic proximity Read

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesisSemantic proximity Read

SARS-CoV-2 Proteins Exploit Host’s Genetic and Epigenetic Mediators for the Annexation of Key Host Signaling PathwaysSemantic proximity Read

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8Semantic proximity Read

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.Semantic proximity Read

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesisSemantic proximity Read