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SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

20 Jul 2023

Abstract excerpt

SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549 cells expressing individual accessory proteins ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). IL11 is a member...

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PMID: 37545510
DOI: 10.3389/fimmu.2023.1220306

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