Article

Alternative Splicing Generates a Nuclear ACSS2 Isoform that Regulates Cardiomyocyte Contractile Gene Programs

2026-07-16

Abstract excerpt

<title>Abstract</title> <p>Cardiomyocytes adapt to physiological and pathological stress through coordinated metabolic and epigenetic remodeling, but how specific metabolic enzymes are tailored to support cardiac gene regulation remains poorly understood. Here we identify a previously uncharacterized long isoform of acetyl-CoA synthetase 2 (ACSS2-L), generated by alternative exon inclusion and selectively express...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15a22748-aa63-5627-ac79-eb5f6fb69f10
DOI: 10.21203/rs.3.rs-10092204/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative Splicing Generates a Nuclear ACSS2 Isoform that Regulates Cardiomyocyte Contractile Gene ProgramsDOI 10.21203/rs.3.rs-10092204/v1Read

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolismSemantic proximity Read

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathySemantic proximity Read

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling.Semantic proximity Read

H2A.Z-dependent and -independent recruitment of metabolic enzymes to chromatin required for histone modificationsSemantic proximity Read

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathySemantic proximity Read

skNAC is a Key Driver of Cardiomyocyte Integrity Against Pathological Cardiac Hypertrophy and Heart FailureSemantic proximity Read

The denitrosylase SCoR2 controls cardioprotective metabolic reprogrammingSemantic proximity Read

Atlas of lysine acetylation in the mouseSemantic proximity Read

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the HeartSemantic proximity Read

ACLY alternative splicing correlates with cancer phenotypes.Semantic proximity Read

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathySemantic proximity Read

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation.Semantic proximity Read