Article
The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone.
mBio - 9 Aug 2016
Bæk Kristoffer T, Bowman Lisa, Millership Charlotte, Dupont Søgaard Mia, Kaever Volkhard, Siljamäki Pia, Savijoki Kirsi, Varmanen Pekka, Nyman Tuula A, Gründling Angelika, Frees Dorte
Abstract excerpt
UNLABELLED: Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria and a promising target for the development of vaccines and antimicrobial compounds against Staphylococcus aureus Here we demonstrate that mutations in the conditionally essential ltaS (LTA synthase) gene arise spontaneously in an S. aureus mutant lacking the ClpX chaperone. A wide variety of ltaS mutations were...
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