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Article

Differential abundance analysis for microbial marker-gene surveys.

Nature methods - 1 Dec 2013

Paulson Joseph N, Stine O Colin, Bravo Héctor Corrada, Pop Mihai

Abstract excerpt

We introduce a methodology to assess differential abundance in sparse high-throughput microbial marker-gene survey data. Our approach, implemented in the metagenomeSeq Bioconductor package, relies on a novel normalization technique and a statistical model that accounts for undersampling-a common...

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PMID: 24076764
DOI: 10.1038/nmeth.2658
PMCID: PMC4010126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24076764-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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