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Comparison of the effectiveness of different normalization methods for metagenomic cross-study phenotype prediction under heterogeneity.

Scientific reports - 25 Mar 2024

Wang Beibei, Sun Fengzhu, Luan Yihui

Abstract excerpt

The human microbiome, comprising microorganisms residing within and on the human body, plays a crucial role in various physiological processes and has been linked to numerous diseases. To analyze microbiome data, it is essential to account for inherent heterogeneity and variability across samples. Normalization methods have been proposed to mitigate these variations and enhance comparability. However, the...

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PMID: 38528097
DOI: 10.1038/s41598-024-57670-2
PMCID: PMC10963794

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