Article

Comparative analysis of PB2 residue 627E/K/V in H5 subtypes of avian influenza viruses isolated in birds and mammals

2023-08-14

Abstract excerpt

Avian influenza viruses (AIV) are naturally found in wild birds, primarily in migratory waterfowl. Although species barriers exist, many AIV have demonstrated the ability to jump from birds into mammalian species. A key contributor to this jump is the adaption of the viral RNA polymerase complex to a new host for efficient replication of its RNA genome. The AIV PB2 gene appears to be essential in this conversion a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 552fccb5-3bd4-5a8a-a417-0b4552de6cfd
DOI: 10.1101/2023.08.11.552972

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative analysis of PB2 residue 627E/K/V in H5 subtypes of avian influenza viruses isolated in birds and mammalsDOI 10.1101/2023.08.11.552972Read

Comparative analysis of PB2 residue 627E/K/V in H5 subtypes of avian influenza viruses isolated from birds and mammalsSemantic proximity Read

An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hostsSemantic proximity Read

The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins.Semantic proximity Read

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammalsSemantic proximity Read

A species-specific signature residue in the PB2 subunit of the bat influenza virus polymerase restricts viral RNA synthesisSemantic proximity Read

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hostsSemantic proximity Read

A 627K variant in the PB2 protein of H9 subtype influenza virus in wild birds.Semantic proximity Read

Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza VirusSemantic proximity Read

The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus LineageSemantic proximity Read

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesSemantic proximity Read

Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in MammalsSemantic proximity Read

An evolutionary approach to identify mammalian adaptive mutations in the avian influenza polymerase complexSemantic proximity Read