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Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling

3 Feb 2017

Abstract excerpt

Podocyte dysfunction results in glomerular diseases accounted for 90% of end-stage kidney disease. The evolutionarily conserved Notch signalling makes a crucial contribution in podocyte development and function. However, the underlying mechanism of Notch pathway modulating podocyte differentiation remains less obvious. Autophagy, reported to be related with Notch signalling pathways in different animal models, is...

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PMID: 28158917
DOI: 10.1111/jcmm.13061

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