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Article

FOXA1 overexpression suppresses interferon signaling and immune response in cancer

8 Jun 2021

Abstract excerpt

Androgen receptor-positive prostate cancer (PCa) and estrogen receptor-positive luminal breast cancer (BCa) are generally less responsive to immunotherapy compared with certain tumor types such as melanoma. However, the underlying mechanisms are not fully elucidated. In this study, we found that FOXA1 overexpression inversely correlated with interferon (IFN) signature and antigen presentation gene expression in...

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PMID: 34101624
DOI: 10.1172/jci147025

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