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Resistance to TOP-1 Inhibitors: Good Old Drugs Still Can Surprise Us

13 Apr 2023

Abstract excerpt

Irinotecan (SN-38) is a potent and broad-spectrum anticancer drug that targets DNA topoisomerase I (Top1). It exerts its cytotoxic effects by binding to the Top1-DNA complex and preventing the re-ligation of the DNA strand, leading to the formation of lethal DNA breaks. Following the initial response to irinotecan, secondary resistance is acquired relatively rapidly, compromising its efficacy. There are several...

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PMID: 37108395
DOI: 10.3390/ijms24087233

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