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Nucleoside-based anticancer drugs: Mechanism of action and drug resistance

9 Aug 2023

Abstract excerpt

Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent therapeutic agents since their introduction in 1950, deployed widely in the treatment of diverse diseases such as cancers, myelodysplastic syndromes, multiple sclerosis, and viral infections. These antimetabolites establish complex interactions with cellular molecular constituents, primarily via activation of phosphorylation...

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PMID: 37567317
DOI: 10.1016/j.bcp.2023.115741

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