Article

T-cell responses are insufficient to generate protective immunity to SARS-CoV-2

2025-11-26

Abstract excerpt

<title>Abstract</title> <p>Neutralizing antibodies are established correlates of protection against SARS-CoV-2, yet T-cell responses are also thought to contribute substantially to limiting disease severity and enhancing durability of protection. To examine whether cellular immunity alone can confer protection, we engineered DNA vaccines encoding modified Spike proteins, including C-terminal truncation (SARS-CoV-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14e979b1-accd-5866-b502-0713a29a6a5a
DOI: 10.21203/rs.3.rs-8158863/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

T-cell responses are insufficient to generate protective immunity to SARS-CoV-2DOI 10.21203/rs.3.rs-8158863/v1Read

DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in miceSemantic proximity Read

T cell-mediated protection against lethal SARS-CoV-2 challenge by a synthetic long peptide vaccine targeting conserved CD4+ and CD8+ T cell epitopesSemantic proximity Read

Combination of a Sindbis-SARS-CoV-2 spike vaccine and αOX40 antibody elicits protective immunity against SARS-CoV-2 induced disease and potentiates long-term SARS-CoV-2-specific humoral and T-cell immunitySemantic proximity Read

A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infectionSemantic proximity Read

Epitope-Focused Immunogens Confer Broad Protection against CoronavirusesSemantic proximity Read

Single-epitope T cell–based vaccine protects against SARS-CoV-2 infection in a preclinical animal modelSemantic proximity Read

Nucleocapsid-specific humoral responses improve the control of SARS-CoV-2Semantic proximity Read

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccineSemantic proximity Read

A Pan-Beta-Coronavirus Vaccine Bearing Conserved and Asymptomatic B- and T-Cell Epitopes Protect Against Highly Pathogenic Delta and Highly Transmissible Omicron SARS-CoV-2 Variants of ConcernSemantic proximity Read

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in miceSemantic proximity Read

Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responsesSemantic proximity Read

Cellular and humoral immunogenicity of a candidate DNA Vaccine Expressing SARS-CoV-2 Spike Subunit 1Semantic proximity Read