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Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

2021-12-28

Abstract excerpt

The emergence of SARS-CoV-2 variants of concern (VOCs) that escape pre-existing antibody neutralizing responses increases the need for vaccines that target conserved epitopes and induce cross-reactive B- and T-cell responses. We used a computational approach and sequence alignment analysis to design a new-generation subunit vaccine targeting conserved sarbecovirus B- and T-cell epitopes from Spike (S) and Nucleoca...

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Identifiers and source

Literature Corpus work
674b85f0-cf8c-5084-8846-75103522728b
DOI
10.1101/2021.12.28.474244
Open publication

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Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccineDOI 10.1101/2021.12.28.474244
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