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Article

Single-epitope T cell–based vaccine protects against SARS-CoV-2 infection in a preclinical animal model

9 Apr 2023

Abstract excerpt

Currently authorized COVID-19 vaccines induce humoral and cellular responses to epitopes in the SARS-CoV-2 spike protein, though the relative roles of antibodies and T cells in protection are not well understood. To understand the role of vaccine-elicited T cell responses in protection, we established a T cell-only vaccine using a DC-targeted lentiviral vector expressing single CD8+ T cell epitopes of the viral...

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PMID: 37036004
DOI: 10.1172/jci.insight.167306

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