Back to search

Article

Trehalose-6-phosphate synthase promotes thermotolerance by governing glycolytic flux in <i>Cryptococcus deneoformans</i>

2026-07-20

Abstract excerpt

Growth at physiologically relevant temperatures is essential for fungal pathogenesis and is controlled by several cellular factors. The evolution of fungal thermotolerance is concerning as warming environments may promote the emergence of new pathogens. Trehalose, a disaccharide absent in mammals, plays a central role in thermotolerance by stabilizing proteins and membranes during heat stress. Trehalose is synthes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
14dbc99f-6994-507e-912d-135e48efc801
DOI
10.64898/2026.07.15.738695
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Trehalose-6-phosphate synthase promotes thermotolerance by governing glycolytic flux in <i>Cryptococcus deneoformans</i>DOI 10.64898/2026.07.15.738695
The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>Semantic proximity
Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans.Semantic proximity
Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in <i>C. neoformans</i> during thermal stressSemantic proximity
Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.Semantic proximity
A trade-off between proliferation and defense in the fungal pathogen <i>Cryptococcus</i> at alkaline pH is controlled by the transcription factor GAT201Semantic proximity
A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen <i>Cryptococcus neoformans</i>Semantic proximity
From Glacier to Sauna: RNA-Seq of the Human Pathogen Black Fungus Exophiala dermatitidis under Varying Temperature Conditions Exhibits Common and Novel Fungal ResponseSemantic proximity
Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.Semantic proximity
Long-read whole-genome sequencing offers novel insights into the biology, stress adaptation, and virulence of neurotropic dematiaceous fungi associated with primary cerebral phaeohyphomycosisSemantic proximity
Phenotypic characterization of <i>HAM1</i> , a novel mating regulator of the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity
Systematic profiling of WD40 proteins reveals Wcp1, a cyclophilin linking CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformansSemantic proximity
Roles of P-body factors in <i>Candida albicans</i> filamentation and stress responseSemantic proximity
Select a neighboring publication to make it the new centre.