Article

DNA Polymerase Beta Catalytic and Fidelity Mutations Drive Platinum Specific Drug Sensitivity

2026-06-19

Abstract excerpt

With the advent of genome sequencing and its widespread use in the clinic, there is a great need to identify mutational biomarkers that predict therapeutic responses. DNA polymerase Beta (Polβ) and the base excision repair (BER) pathway have been previously implicated as modulators of response to platinum-based chemotherapies and are mutated in as high as 30% of cancers. Here, we show in a triple-negative breast c...

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Literature Corpus work: 14ccafe5-e11c-552d-b5e5-b016d9924e23
DOI: 10.64898/2026.06.15.732403

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