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Article

Platinum Resistance: The Role of DNA Repair Pathways

1 Mar 2008

Abstract excerpt

Although platinum chemotherapeutic agents such as carboplatin, cisplatin, and oxaliplatin are used to treat a broad range of malignant diseases, their efficacy in most cancers is limited by the development of resistance. There are multiple factors that contribute to platinum resistance but alterations of DNA repair processes have been known for some time to be important in mediating resistance. Recently acquired...

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PMID: 18316546
DOI: 10.1158/1078-0432.ccr-07-2238

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