Article

Sex-specific signatures of brain-wide induction of ΔFOSB and altered co-activation networks in a mouse model for exercise training

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Physical exercise training promotes brain health, yet the underlying mechanisms remain incompletely understood. Repeated neuronal activation results in accumulation of the transcription factor ΔFOSB, a long-lived splice variant of FOSB. We have previously demonstrated in rats that long-term voluntary wheel running (VWR), a behavioral paradigm that mimics exercise training in humans, altered ΔFOS...

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Literature Corpus work: 57903f64-163f-5fc9-90ce-451ce546a213
DOI: 10.64898/2026.02.24.707648

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