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Article

Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.

Gastroenterology - 1 Nov 2010

Rao Archana S, Wong Banny S, Camilleri Michael, Odunsi-Shiyanbade Suwebatu T, McKinzie Sanna, Ryks Michael, Burton Duane, Carlson Paula, Lamsam Jesse, Singh Ravinder, Zinsmeister Alan R

Abstract excerpt

BACKGROUND & AIMS: Sodium chenodeoxycholate (CDC) accelerates colonic transit in health. Our aim was to examine pharmacodynamics (colonic transit, bowel function) and pharmacogenetics of CDC in constipation-predominant irritable bowel syndrome (IBS-C). METHODS: In a double-blind placebo-controlled study, 36 female patients with IBS-C were randomized to treatment with delayed-release oral formulations of placebo,...

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Identifiers

PMID: 20691689
DOI: 10.1053/j.gastro.2010.07.052
PMCID: PMC3189402

Genes

FGF19
FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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