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Stratification of alopecia areata reveals involvement of CD4 T cell populations and altered faecal microbiota

6 Oct 2022

Abstract excerpt

Alopecia areata (AA) is an immune-mediated disease that causes non-scarring hair loss. Autoreactive CD8 T cells are key pathogenic effectors in the skin, and AA has been associated both with atopy and with perturbations in intestinal homeostasis. This study aimed to investigate mechanisms driving AA by characterizing the circulating immunophenotype and faecal microbiome, and by stratifying AA to understand how...

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PMID: 36200950
DOI: 10.1093/cei/uxac088

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