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Article

Alopecia areata: An autoimmune insult, molecular insights, and therapeutic horizons.

Human immunology - 1 Oct 2026

Usman Muhammad, Khattak Touseef Ahmad, Fozan Muhammad, Ali Hamad

Abstract excerpt

Alopecia areata (AA) is a relapsing autoimmune disease characterized by non-scarring loss of hair following the collapse of immune privilege of the anagen hair follicles. This review summarizes recent molecular findings linking follicular stress to an atypical cytotoxic response, with special emphasis on the role of CD8 + NKG2D+ T cells, stress-induced ligands (MICA/ULBPs), and a Th1 cytokine circuit triggered by...

Read the complete abstract on PubMed

Topics

Humans
Alopecia Areata
Animals
NK Cell Lectin-Like Receptor Subfamily K
CD8-Positive T-Lymphocytes
Hair Follicle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Autoimmune Diseases

Signal Transduction

Oxidative Stress

Genetic Predisposition to Disease

Source

Identifiers

PMID: 42628384
DOI: 10.1016/j.humimm.2026.112045

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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