Article

Human Mitochondrial AAA+ ATPase SKD3/CLPB forms Nucleotide-Stabilized Dodecamers

2021-12-16

Abstract excerpt

SKD3, also known as human CLPB, belongs to the AAA+ family of A TPases a ssociated with various a ctivities. Mutations in the SKD3/CLPB gene cause 3-methylglutaconic aciduria type VII and congenital neutropenia. SKD3 is upregulated in acute myeloid leukemia, where it contributes to anti-cancer drug resistance. SKD3 resides in the mitochondrial intermembrane space, where it forms ATP-dependent high-molecular we...

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Literature Corpus work: 58fdb721-a727-5443-831b-e9e2592048aa
DOI: 10.1101/2021.12.16.472980

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