Article

Multiplexed Quantification of Variant Abundance in the Globin Gene Family: Integrating Saturation Mutagenesis with Cross-Paralog Prediction

2026-08-24

Abstract excerpt

Widespread genetic testing has expanded variant identification, yet functional characterization remains a bottleneck in genome guided medicine. Here, we present a modified Variant Abundance by Massively Parallel Sequencing (VAMP-seq) platform integrating experimental and computational approaches for high-resolution abundance profiling of protein variants. Utilizing a lentiviral integration system, we systematicall...

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Literature Corpus work: 146597ae-9eac-52b6-ae27-f3bc04d20665
DOI: 10.64898/2026.08.19.745862

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Multiplexed Quantification of Variant Abundance in the Globin Gene Family: Integrating Saturation Mutagenesis with Cross-Paralog PredictionDOI 10.64898/2026.08.19.745862Read

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