Article

A structure and function-based complete mutational map of Human Hemoglobin using AI

2025-10-01

Abstract excerpt

Hemoglob+in (Hb), a well-characterized protein central to oxygen transport and molecular medicine, serves as a model for studying how sequence variations influence protein structure and function. Its precise activity depends on tightly regulated structural dynamics, which can be disrupted by mutations that give rise to structural hemoglobinopathies—including sickle cell disease, unstable hemoglobins, methemoglobin...

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Literature Corpus work: d5de7efd-f95d-5be6-acd8-ac3927f84e84
DOI: 10.1101/2025.09.30.679504

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