Article

Clinically meaningful metrics of speech in neurodegenerative disease: Quantification of speech intelligibility and naturalness in ataxia

2023-03-29

Abstract excerpt

<h4>Background</h4> Digital biomarkers continue to make headway in the clinic and clinical trials for neurological conditions. Speech is a domain with great promise. <h4>Objectives</h4> Using Friedreich ataxia (FRDA) as an exemplar population, we aimed to align objective measures of speech with markers of disease severity, speech related quality of life and subjective judgements of speech using supervised machine...

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Literature Corpus work: 63d93bec-3208-568a-a3ca-973c7b9faa19
DOI: 10.1101/2023.03.28.23287878

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