Article

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer′s Disease

2025-08-11

Abstract excerpt

Hearing is the largest modifiable mid-life risk factor for Alzheimer′s Disease (AD) yet its link to dementia remains unclear. We identified a neurophysiological biomarker of AD risk using the non-invasive, rapidly acquired, and clinically translatable auditory brainstem response (ABR) in normal hearing knock-in rats (Swedish familial AD risk variant to Amyloid precursor protein (AppS); male and female). Human ABRs...

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Literature Corpus work: 6236b0db-546a-5dca-9ad1-fd3059492cbe
DOI: 10.1101/2025.08.07.669134

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