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Article

sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice.

Cytokine - 1 Jun 2023

Huang Xiaojie, Jia Linyan, Jia Yuanhui, Xu Xianghong, Wang Ruixue, Wei Mengtian, Li Han, Peng Hao, Wei Yingying, He Qizhi, Wang Kai

Abstract excerpt

Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by maternal endothelial dysfunction and end-organ damage. Our previous work demonstrated that PE patient-derived exosomes contained higher levels of soluble FMS-like tyrosine kinase-1 (sFlt-1) and significantly induced endothelial dysfunction and PE development. However, the mechanisms underlying the effect of sFlt-1-enriched exosomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37062152
DOI: 10.1016/j.cyto.2023.156190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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