Article

Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosis

2024-12-03

Abstract excerpt

Survival after lung transplantation is limited by chronic progressive graft failure, termed chronic lung allograft dysfunction (CLAD). Graft-resident mesenchymal cells (MCs) drive CLAD pathogenesis and exhibit stable, dysregulated signaling; however, the transcriptomic and epigenomic drivers behind this fibrogenic transformation remain elusive. Here, we utilize single-cell multi-omic technologies to study gene exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 140b2435-a1dc-5169-b98e-59ada060c064
DOI: 10.1101/2024.11.27.625698

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosisDOI 10.1101/2024.11.27.625698Read

Distinct fibrotic, epithelial and immune transcriptomic programs in phenotypes of chronic lung allograft dysfunctionSemantic proximity Read

Integrative single cell analysis to decode transcriptomic heterogeneity in pulmonary fibrosis across diverse pathologiesSemantic proximity Read

Transcriptomic analyses reveal regional signatures in lung allograft recipientsSemantic proximity Read

Single-cell and spatial transcriptomics resolve airway obliteration in bronchiolitis obliterans syndromeSemantic proximity Read

Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosisSemantic proximity Read

RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulationSemantic proximity Read

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19Semantic proximity Read

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary FibrosisSemantic proximity Read

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosisSemantic proximity Read

T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary FibrosisSemantic proximity Read

Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantationSemantic proximity Read

Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytesSemantic proximity Read