Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway

9 Jun 2022

Abstract excerpt

BACKGROUND: The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers involved in leukemogenesis may thus provide new anticancer strategies. Accumulating evidence suggests that the PRC1 complex member CBX2 is overexpressed in solid tumors and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35681235
DOI: 10.1186/s12943-022-01603-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathwayPMID 35681235Read ↗

SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C RepressionSemantic proximity Read ↗

Exploring the Role of CBX3 as Potential Therapeutic Target in Lung CancerSemantic proximity Read ↗

Cellular signaling and epigenetic regulation of gene expression in leukemiaSemantic proximity Read ↗

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.Semantic proximity Read ↗

Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALLSemantic proximity Read ↗

CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical InteractionsSemantic proximity Read ↗

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.Semantic proximity Read ↗

Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemiaSemantic proximity Read ↗

Chromatin‐related properties of CBP fused to MLL generate a myelodysplastic‐like syndrome that evolves into myeloid leukemiaSemantic proximity Read ↗

The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisisSemantic proximity Read ↗

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid LeukemiaSemantic proximity Read ↗

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.