Article

Impaired store-operated Ca <sup>2+</sup> entry in mouse epidermis leads to reduced epidermal barrier function via Klk activation

2025-10-15

Abstract excerpt

Store-operated Ca 2+ entry (SOCE) is a mechanism by which STIM1/2 detect calcium depletion in the endoplasmic reticulum (ER) and activate ORAI1/TRPC channels on the cell membrane to induce calcium influx into the cytoplasm. This study aimed to investigate SOCE’s role in the skin epidermis in vivo , using female mice with epithelial tissue-specific Stim1 and Stim2 knockout ( Stim1/2 cKO ) and control mice ( Sti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13ccc6a6-d57d-5553-9d0a-ea7dfed98294
DOI: 10.1101/2025.10.14.681588

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired store-operated Ca <sup>2+</sup> entry in mouse epidermis leads to reduced epidermal barrier function via Klk activationDOI 10.1101/2025.10.14.681588Read

Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiationSemantic proximity Read

Orais and STIMs: physiological mechanisms and disease.Semantic proximity Read

The Ca2+ Sensor STIM in Human Diseases.Semantic proximity Read

STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in miceSemantic proximity Read

Physiological and pathophysiological functions of SOCE in the immune system.Semantic proximity Read

STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror DiseasesSemantic proximity Read

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiencySemantic proximity Read

A novel bi-allelic loss-of-function mutation in STIM1 expands the phenotype of STIM1-related diseases.Semantic proximity Read

STIM and ORAI proteins: crucial roles in hallmarks of cancerSemantic proximity Read

Darier's disease: a calcium-signaling perspective.Semantic proximity Read

A Gain-of-Function Mutation in the Ca2+ Channel ORAI1 Causes Stormorken Syndrome with Tubular Aggregates in Mice.Semantic proximity Read

[Immunodeficiencies and pathologies associated with mutations in STIM/ORAI, a membrane complex in the heart of calcium signalling].Semantic proximity Read