Article

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

2019-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in activation induced deaminase (AID) lead to hyper-IgM syndrome type 2 (HIGM2), a rare human primary antibody deficiency. AID-mediated cytosine deamination has been proposed as mediating active demethylation, although evidences both support and cast doubt on such a role. We here made use of HIGM2 B cells to investigate direct AID involvement in active DNA demethylation. HIGM2 naïve an...

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Literature Corpus work: 138514dd-b409-5112-9804-afc084e11b95
DOI: 10.1101/737908

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