Article

Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated <i>in vivo</i>

2023-08-07

Abstract excerpt

SARS-CoV-2 has been proposed to encode ORF10 as the 3’ terminal gene in the viral genome. However, the potential role and even existence of a functional ORF10 product has been the subject of debate. There are significant structural features in the viral genomic RNA that could, by themselves, explain the retention of the ORF10 nucleotide sequences without the need for a functional protein product. To explore this q...

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Literature Corpus work: 13323b3f-8f92-5c9e-8dae-6f11d89e6536
DOI: 10.1101/2023.08.04.551973

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