High-grade serous ovarian cancer cell lines exhibit heterogeneous responses to growth factor stimulation

Abstract excerpt

BACKGROUND: The factors driving the onset and progression of ovarian cancer are not well understood. Recent reports have identified cell lines that are representative of the genomic pattern of high-grade serous ovarian cancer (HGSOC), in which greater than 90 % of tumors have a mutation in TP53. However, many of these representative cell lines have not been widely used so it is unclear if these cell lines capture...

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