Article

Human Plasma and Recombinant Hemopexins: Heme Binding Revisited

2020-12-15

Abstract excerpt

Abstract: Plasma hemopexin (HPX) is the key antioxidant protein of the endogenous clearance pathway that limits the deleterious effects of heme released from hemoglobin and myoglobin. During intra-vascular hemolysis, heme partitioning to protein and lipid increases as the plasma concentration of HPX declines. Therefore, the development of HPX as a replacement therapy during high heme stress could be a relevant int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 132ca007-ab76-5dc8-82b4-b335431eeae9
DOI: 10.20944/preprints202012.0370.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Plasma and Recombinant Hemopexins: Heme Binding RevisitedDOI 10.20944/preprints202012.0370.v1Read

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.Semantic proximity Read

Haptoglobin: From hemoglobin scavenging to human health.Semantic proximity Read

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.Semantic proximity Read

HaptoglobinSemantic proximity Read

Haptoglobin-related protein in human plasma correlates to haptoglobin concentrations and phenotypes.Semantic proximity Read

A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin.Semantic proximity Read

Human haptoglobin structure and function--a molecular modelling study.Semantic proximity Read

Differential regulation of redox proteins and chaperones in HbEβ‐thalassemia erythrocyte proteomeSemantic proximity Read

Re-evalution of the measurement of haptoglobin in human plasma samples.Semantic proximity Read

The interplay between molten globules and heme disassociation defines human hemoglobin disassemblySemantic proximity Read

Antioxidant role of human haptoglobin.Semantic proximity Read

Accurate disulfide formation in Escherichia coli: overexpression and characterization of the first domain (HF6478) of the multiple Kazal-type inhibitor LEKTI.Semantic proximity Read