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Article

Differential regulation of redox proteins and chaperones in HbEβ‐thalassemia erythrocyte proteome

28 Jan 2010

Abstract excerpt

PURPOSE: In (hemoglobin, Hb) HbEβ-thalassemia, HbE (β-26 Glu→Lys) interacts with β-thalassemia to produce clinical manifestation of varying severity. This is the first proteomic effort to study changes in protein levels of erythrocytes isolated from HbEβ-thalassemic patients compared to normal. EXPERIMENTAL DESIGN: We have used 2-DE and MALDI-MS/MS-based techniques to investigate the differential proteome...

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Share to Erythrocyte Function and Pathophysiology
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Identifiers

PMID: 21137065
DOI: 10.1002/prca.200900073

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