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Article

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

1 Jun 2017

Abstract excerpt

The presence of dark melanin (eumelanin) within human epidermis represents one of the strongest predictors of low skin cancer risk. Topical rescue of eumelanin synthesis, previously achieved in "redhaired" Mc1r-deficient mice, demonstrated significant protection against UV damage. However, application of a topical strategy for human skin pigmentation has not been achieved, largely due to the greater barrier...

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PMID: 28614705
DOI: 10.1016/j.celrep.2017.05.042

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