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Article

IFN-γ signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation

28 Jan 2014

Abstract excerpt

Cellular homeostasis is an outcome of complex interacting processes with nonlinear feedbacks that can span distinct spatial and temporal dimensions. Skin tanning is one such dynamic response that maintains genome integrity of epidermal cells. Although pathways underlying hyperpigmentation cascade are recognized, negative feedback regulatory loops that can dampen the activated melanogenesis process are not...

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PMID: 24474804
DOI: 10.1073/pnas.1304988111

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