The multiple roles of autophagy in uveal melanoma and the microenvironment

Abstract excerpt

PURPOSE: Uveal melanoma (UM) is the most common primary malignant intraocular tumor in adults, and effective clinical treatment strategies are still lacking. Autophagy is a lysosome-dependent degradation system that can encapsulate abnormal proteins, damaged organelles. However, dysfunctional autophagy has multiple types and plays a complex role in tumorigenicity depending on many factors, such as tumor stage,...

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• Autophagy in Disease and Therapy
• Microtubule and mitosis dynamics
• Ocular Oncology and Treatments