Article
Transformation or tumor heterogeneity: Mutations in EGFR, SOX2, TP53, and RB1 persist in the histological rapid conversion from lung adenocarcinoma to small-cell lung cancer.
Thoracic cancer - 1 Apr 2023
Hao Lidan, Chen Haiyang, Wang Lili, Zhou Hanqiong, Zhang Zhe, Han Jing, Hou Jiabao, Zhu Yichen, Zhang He, Wang Qiming
Abstract excerpt
The transformation from non-small-cell lung cancer (NSCLC) to small-cell lung cancer (SCLC) is one of the mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) resistance. Previous studies exhibited that the median transformation time was 17.8 months for NSCLC to SCLC. Here we introduced a case of lung adenocarcinoma (LADC) with EGFR19 exon deletion mutation in which the...
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