Article

Dysregulated flow responses drive pathogenesis in a cellular model of Sturge–Weber syndrome

2026-06-04

Abstract excerpt

Vascular diseases comprise a broad spectrum of conditions associated with organ dysfunction, yet how endothelial responses to mechanical forces drive their pathogenesis remains unclear. Sturge–Weber syndrome (SWS), a flow-associated vascular malformation caused by somatic GNAQ mutations, provides a model to investigate this question. Here, using isogenic induced pluripotent stem cell–derived endothelial cells (ECs...

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Literature Corpus work: 128f7b90-4498-5443-9b15-109aa9814397
DOI: 10.64898/2026.06.02.729175

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