Article

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

2023-03-02

Abstract excerpt

Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti-fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a high cont...

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Literature Corpus work: 1264b36d-2d7a-50be-b0cb-d66f353a6605
DOI: 10.1101/2023.03.01.530599

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