Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

Abstract excerpt

Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti-fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Fibrosis and Remodeling
• Share to Cellular Mechanics and Interactions
• Share to Viral Infectious Diseases and Gene Expression in Insects