Article

Collective amoeboid dynamics drives colonization of drug-resistant ovarian cancer cells

2024-10-06

Abstract excerpt

Epithelial ovarian cancer (EOC) is characterized by resistance to platinum-based therapy, resulting in rapid progression and poor survival. Here, we ask whether drug resistance and invasiveness coevolve to drive metastasis. Selection experiments involving pulsed carboplatin exposure established isogenic chemoresistant variants of lines, which typify high-grade serous ovarian carcinoma (HGSOC), the most aggressive...

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Literature Corpus work: 125b0543-e289-521e-adc6-2a2ba220a453
DOI: 10.1101/2024.10.05.616763

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