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Article

Chemoresistance is mediated by ovarian cancer leader cells in vitro

1 Sept 2021

Abstract excerpt

BACKGROUND: Leader cells are a subset of cancer cells that coordinate the complex cell-cell and cell-matrix interactions required for ovarian cancer migration, invasion, tumour deposition and are negatively associated with progression-free survival and response to therapy. Emerging evidence suggests leader cells may be enriched in response to chemotherapy, underlying disease recurrence following treatment....

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PMID: 34470672
DOI: 10.1186/s13046-021-02086-3

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