Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

INPP5E regulates phosphoinositide-dependent cilia transition zone function.

The Journal of cell biology - 2 Jan 2017

Dyson Jennifer M, Conduit Sarah E, Feeney Sandra J, Hakim Sandra, DiTommaso Tia, Fulcher Alex J, Sriratana Absorn, Ramm Georg, Horan Kristy A, Gurung Rajendra, Wicking Carol, Smyth Ian, Mitchell Christina A

Abstract excerpt

Human ciliopathies, including Joubert syndrome (JBTS), arise from cilia dysfunction. The inositol polyphosphate 5-phosphatase INPP5E localizes to cilia and is mutated in JBTS. Murine Inpp5e ablation is embryonically lethal and recapitulates JBTS, including neural tube defects and polydactyly; however, the underlying defects in cilia signaling and the function of INPP5E at cilia are still emerging. We report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Smoothened Receptor
Share to Eye Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Diseases, Cystic

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Phosphatidylinositol Phosphates

Share to Retinal Pigment Epithelium

Share to Second Messenger Systems

Share to Zinc Finger Protein Gli2

Source

Open in PubMed Open full text

Identifiers

PMID: 27998989
DOI: 10.1083/jcb.201511055
PMCID: PMC5223597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

INPP5E regulates phosphoinositide-dependent cilia transition zone function.PMID 27998989Read ↗

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.Semantic proximity Read ↗

Regulation of INPP5E in Ciliogenesis, Development, and Disease.Semantic proximity Read ↗

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse.Semantic proximity Read ↗

Evidence of a role of inositol polyphosphate 5-phosphatase INPP5E in cilia formation in zebrafish.Semantic proximity Read ↗

The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.Semantic proximity Read ↗

INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability.Semantic proximity Read ↗

Loss of INPP5E affects photoreceptor outer segment membrane biogenesis in iPSC-derived human retinal organoidsSemantic proximity Read ↗

Deletion of INPP5E in the murine retina impairs axoneme formation and prevents photoreceptor disc morphogenesisSemantic proximity Read ↗

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.Semantic proximity Read ↗

Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies.Semantic proximity Read ↗

Multiple Ciliary Localization Signals Control INPP5E Ciliary TargetingSemantic proximity Read ↗

INPP5E controls ciliary localization of phospholipids and odor response kinetics in a mouse model of Joubert syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.